Different Voltage-dependent Inhibition by Dihydropyridines of Human Ca2+ Channel Splice Variants
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چکیده
منابع مشابه
The effect of stress and glucocorticoids on modulation of pain in mice: Interaction with activation of voltage dependent Ca2+ channel
Previous studies indicated that stress and glucocorticoids have modulatory effects on acute pain. The aim of present study was to determine the interaction between stress and glucocorticoids with activation of voltage dependent Ca2+ channel on modulation of acute pain in mice. Male albino mice (25-30 g) were used for this experiment. Tail flick and hot plate were used for evaluation of analgesi...
متن کاملThe effect of stress and glucocorticoids on modulation of pain in mice: Interaction with activation of voltage dependent Ca2+ channel
Previous studies indicated that stress and glucocorticoids have modulatory effects on acute pain. The aim of present study was to determine the interaction between stress and glucocorticoids with activation of voltage dependent Ca2+ channel on modulation of acute pain in mice. Male albino mice (25-30 g) were used for this experiment. Tail flick and hot plate were used for evaluation of analgesi...
متن کاملβ Subunits Functionally Differentiate Human Kv4.3 Potassium Channel Splice Variants
The human ventricular cardiomyocyte transient outward K+ current (Ito) mediates the initial phase of myocyte repolarization and its disruption is implicated in Brugada Syndrome and heart failure (HF). Human cardiac Ito is generated primarily by two Kv4.3 splice variants (Kv4.3L and Kv4.3S, diverging only by a C-terminal, S6-proximal, 19-residue stretch unique to Kv4.3L), which are differentiall...
متن کاملPhosphorylation and dephosphorylation of dihydropyridine-sensitive voltage-dependent Ca2+ channel in skeletal muscle membranes by cAMP- and Ca2+-dependent processes.
The phosphorylation and dephosphorylation of the dihydropyridine-sensitive Ca2+ channel was studied in transverse-tubule membranes isolated from rabbit skeletal muscle. Exposure of these membranes to either the cAMP-dependent protein kinase or a Ca2+/calmodulin-dependent protein kinase resulted in a rapid phosphorylation of a protein with properties similar to the major component of the skeleta...
متن کاملMineralocorticoid receptor splice variants in different human tissues.
The mineralocorticoid receptor (MR), a member of the steroid receptor family, acts as a transcription factor and mediates both aldosterone and cortisol effects. Aldosterone specificity in some tissues results from the inactivation of competing cortisol into cortisone by 11beta-hydroxysteroid dehydrogenase. In other tissues MR and the glucocorticoid receptor show overlapping physiological effect...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.18.10540